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46 , the ability of superoxide dismutase (SOD) to prevent the reduction of the nitroblue tetrazolium dye to diformazan, which is mediated by phenazine methylsulfate (PMS), was used to assess SOD activity

Further mechanistic research demonstrates that NPGE reduces cerebral IR injury by inhibiting ferroptosis-mediated neuroinflammation through the NRF2/HO-1 signaling pathway (Zhang et al., 2024)

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Challenges and future prospects While AC demonstrates significant therapeutic potential across a range of diseases due to its antioxidant, anti-inflammatory, neuroprotective, and anticancer properties, several challenges impede its clinical translation, most notably its poor bioavailability and the limited availability of robust clinical data (Alipieva et al